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The Virginia Tech Hokies will take on the Middle Tenn. Blue Raiders at 2 p.m. ET on Saturday at Lane Stadium/Worsham Field. The Hokies are 1-0 overall and 1-0 at home, while MTSU is 1-0 overall and 0-0 on the road. Virginia Tech is 5-1 in its last six games played in September, while the Blue Raiders are just 4-10 in their last 14 meetings against an opponent from the ACC. 

The Hokies are favored by 20 points in the latest Virginia Tech vs. MTSU odds from Caesars Sportsbook, and the over-under is set at 54.5. Before entering any MTSU. vs. Virginia Tech picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Virginia Tech vs.  MTSU. You can head to SportsLine to see its picks. Here are several college football odds for Virginia Tech vs. MTSU:

  • Virginia Tech vs. MTSU spread: Virginia Tech -20
  • Virginia Tech vs. MTSU over-under: 54.5 points

What you need to know about Virginia Tech

Virginia Tech beat the North Carolina Tar Heels 17-10 last Friday. Virginia Tech QB Braxton Burmeister was slinging it as he passed for one TD and 169 yards on 19 attempts in addition to rushing for one TD and 53 yards. The Hokies also created havoc on the defensive side of the ball, securing three interceptions against the Tar Heels. 

The Hokies are 10-1 in their last 11 games against an opponent from Conference USA. However, Virginia Tech is just 1-4 against the spread in its last five games played on a Saturday. In addition, the Hokies are 2-4 against the spread in their last six games when playing as the favorite. 

What you need to know about Middle Tenn.

Meanwhile, the Blue Raiders simply couldn't be stopped last week, as they easily beat the Monmouth Hawks at home 50-15. MTSU quarterback Bailey Hockman did work as he passed for three TDs and 215 yards on 23 attempts. Wideout Jaylin Lane also had a big day for the Blue Raiders, recording four receptions for 91 yards and a touchdown. 

Middle Tennessee State enters Saturday's matchup having covered the spread in six of its last eight games overall. The Blue Raiders are also 13-5 against the spread in their last 18 games played in Week 2.  

How to make Middle Tenn. vs. Virginia Tech picks

The model has simulated Virginia Tech vs. Middle Tenn. 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Virginia Tech vs. MTSU? And which side of the spread hits almost 60 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.